Altered airway mechanics in the context of obesity and asthma
Jason H. T. Bates, Ubong Peters, Nirav Daphtary, Erick S. MacLean, Kevin Hodgdon, David A. Kaminsky, Swati A. Bhatawadekar, Anne E. Dixon
Abstract
Why only a subset of severely obese subjects develop late-onset nonallergic (LONA) asthma remains unknown, although it is widely assumed that compression of the lungs by the chest wall is somehow involved. We show that lung compression is common to obese individuals both without asthma and with LONA asthma but that those with LONA asthma may have increased airway wall compliance and possibly also a reduced ability to recruit collapsed lung.
Topics & Concepts
AsthmaMedicineContext (archaeology)AirwayObesityRespiratory physiologyLungInternal medicineAnesthesiaBiologyPaleontologyAsthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchRespiratory and Cough-Related Research