RNAi-mediated control of CRISPR functions
Xinbo Huang, Zhicong Chen, Yuchen Liu
Abstract
: Our study provides an efficient molecular switch for conditional regulation of CRISPR activities in mammalian cells and also presents potentially useful approaches for solving current key issues of off-target effects and low targeting efficiency.
Topics & Concepts
CRISPRGenome editingCas9RNA interferenceBiologyComputational biologySubgenomic mRNAmicroRNAGeneRNAGeneticsCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery