Design of a self-sufficient hydride-shuttling cascade for concurrent bioproduction of 7,12-dioxolithocholate and<scp>l</scp>-<i>tert</i>-leucine
Zhi‐Neng You, Ke Zhou, Yu Han, Bing-Yi Yang, Qi Chen, Jiang Pan, Xiao‐Long Qian, Chun‐Xiu Li, Jian‐He Xu
Abstract
A highly atom-economic self-sufficient hydride-shuttling cascade was designed to concurrently obtain 7,12-dioxo-lithocholic acid and<sc>l</sc>-<italic>tert</italic>-leucine using only inorganic ammonium as the sacrificial agent and generating water as the by-product.
Topics & Concepts
BioproductionChemistryHydrideCascadeLeucineCombinatorial chemistryStereochemistryOrganic chemistryBiochemistryChromatographyAmino acidHydrogenBiochemical and Molecular ResearchCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins Research