Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
Gang Su, Xiaohong Ma, Haidong Wei
Abstract
Lung injury and inflammation are complex pathological processes. The influence and crosstalk between various cells form a characteristic microenvironment. Extracellular vesicles from different cell sources in the microenvironment carry multiple cargo molecules, which affect the pathological process through different pathways. Here, we mainly discussed the mechanism of crosstalk between alveolar epithelial cells and different immune cells through extracellular vesicles in lung inflammation and reviewed the mechanism of extracellular vesicles released by blood and airways on lung inflammation. Finally, the role of extracellular vesicles in viral infection of the lung was also described.
Topics & Concepts
InflammationCrosstalkExtracellularCell biologyMicrovesiclesExtracellular vesiclesImmune systemVesicleExtracellular vesicleLungBiologyImmunologyChemistryMedicineBiochemistrymicroRNAInternal medicineOpticsPhysicsMembraneGeneExtracellular vesicles in diseaseMicroRNA in disease regulationViral Infections and Vectors