Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents
Min Wang, Tongtong Liu, Shiming Chen, Mingfei Wu, Jianfei Han, Zeng Li
Topics & Concepts
ChemistryGSK-3OxadiazoleNeuroprotectionGlycogen synthaseChemical synthesisPotencyKinasePharmacologyEnzymeBiochemistryStereochemistryCombinatorial chemistryIn vitroOrganic chemistryMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsNuclear Receptors and Signaling