Design, synthesis, and biological evaluation of novel pleuromutilin derivatives with methicillin-resistant Staphylococcus aureus -targeting phenol linker groups
Yunpeng Yi, Jiaming Zhang, Shuqian Lin, Haiting Wang, Guiyu Li, Shifa Yang, Ruofeng Shang, Rongling Zhang, Fei Li, Rongling Zhang, Fei Li
Topics & Concepts
ChemistryLinkerStaphylococcus aureusMethicillin-resistant Staphylococcus aureusCombinatorial chemistryPhenolAntimicrobialChemical synthesisStaphylococcal infectionsAntibacterial agentStereochemistryAntibioticsIn vitroBacteriaOrganic chemistryBiochemistryComputer scienceGeneticsBiologyOperating systemVeterinary medicine and infectious diseasesSynthesis and Biological EvaluationToxin Mechanisms and Immunotoxins