Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition–Transamination Reactions
Carlos J. Moreno, Karel Hernández, Simon J. Charnok, Samantha Gittings, Michael Bolte, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés
Abstract
, using l-Asp as a substrate to regenerate l-Glu. The γ-hydroxy-α-amino acids thus obtained were transformed into chiral α-amino-γ-butyrolactones, structural motifs found in many biologically active compounds and valuable intermediates for the synthesis of pharmaceutical agents.
Topics & Concepts
TransaminationChemistryAldol reactionPseudomonas putidaAmino acidAldolase AEnantioselective synthesisBenzylamineNitrilasePseudomonas fluorescensOrganic chemistryStereochemistryEnzymeBiochemistryCatalysisBacteriaGeneticsBiologyAmino Acid Enzymes and MetabolismEnzyme Structure and FunctionMicrobial Metabolic Engineering and Bioproduction