Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation
Hongming Lv, Chao Zhu, Wei Wei, Xiaohong Lv, Qinlei Yu, Xuming Deng, Xinxin Ci
Topics & Concepts
Oxidative stressChemistryWestern blotKEAP1TXNIPApoptosisPharmacologyAcetaminophenIn vivoMalondialdehydeInflammasomeTUNEL assayHepatoprotectionGlutathioneMolecular biologyBiochemistryBiologyThioredoxinEnzymeTranscription factorBiotechnologyGeneReceptorDrug-Induced Hepatotoxicity and ProtectionGenomics, phytochemicals, and oxidative stressInflammasome and immune disorders