A novel tumor suppressor encoded by a 1p36.3 lncRNA functions as a phosphoinositide-binding protein repressing AKT phosphorylation/activation and promoting autophagy
Lili Li, Xing‐sheng Shu, Hua Geng, Jianming Ying, Lei Guo, Jie Luo, Tingxiu Xiang, Longtao Wu, B. Y. Brigette, Anthony T.�C. Chan, Xiao‐Feng Zhu, Richard F. Ambinder, Qian Tao
Topics & Concepts
BiologyPI3K/AKT/mTOR pathwayProtein kinase BAutophagyCancer researchWnt signaling pathwayTumor suppressor geneCell biologySignal transductionGeneApoptosisCarcinogenesisGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerAutophagy in Disease and Therapy