Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis
Daniela Mokrá, Marta Jošková, Juraj Mokrý
Abstract
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways, and nuclear transcription factors, EGCG possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, and tissue-protective properties which may be useful in the treatment of various diseases, particularly in cancer, and neurological, cardiovascular, respiratory, and metabolic disorders. This article reviews current information on the biological effects of EGCG in the above-mentioned disorders in relation to molecular pathways controlling inflammation, oxidative stress, and cell apoptosis.
Topics & Concepts
Epigallocatechin gallateOxidative stressInflammationApoptosisPolyphenolAntioxidantIntracellularSignal transductionPharmacologyChemistryBiologyBiochemistryCell biologyImmunologyTea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesTannin, Tannase and Anticancer Activities