A diversity oriented clicking strategy: the stereoselective synthesis of highly-functionalised olefins from 2-substituted-alkynyl-1-sulfonyl fluorides
Christopher J. Smedley
Abstract
)-1-(dimethylamino)-3-oxo-3-substitutedprop-1-ene-2-sulfonyl fluorides from DMSO and DMF, respectively. The reactions proceed expediently to give single products in excellent yield without the need for chromatographic purification. Furthermore, the utility of the DMSO derived products is demonstrated in the synthesis of synthetically valuable β-keto sulfonyl fluorides under hydrogenation conditions in excellent yields.
Topics & Concepts
SulfonylStereoselectivityChemistryFluorideYield (engineering)Organic chemistryCombinatorial chemistryCatalysisMaterials scienceInorganic chemistryAlkylMetallurgyClick Chemistry and ApplicationsSulfur-Based Synthesis TechniquesFluorine in Organic Chemistry