Macrophage KDM2A promotes atherosclerosis via regulating FYN and inducing inflammatory response
Yuzhou Xue, Yuce Peng, Ling Jin, Lin Liu, Qian Liu, Xiaofan Yuan, Jingyu Wang, Mingming Zhao, Wenming Zhang, Suxin Luo, Yuanjing Li, Minghao Luo, Longxiang Huang
Abstract
mice fed a high-fat diet apparently attenuated plaque progression. Furthermore, the genetic association of KDM2A with atherosclerosis was validated by Mendelian randomization and colocalization analysis. A group of small molecules with the potential to target KDM2A has been identified through virtual screening, offering promising strategies for atherosclerosis treatment. The current study provides the novel role of KDM2A in macrophage inflammatory response of atherosclerosis through transcriptional regulation of FYN.
Topics & Concepts
FYNInflammatory responseMacrophageInflammationBiologyImmunologyCell biologySignal transductionGeneticsIn vitroProto-oncogene tyrosine-protein kinase SrcImmune cells in cancerAtherosclerosis and Cardiovascular Diseases