Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation
Chih‐Jie Shen, Ren‐Hao Chan, Bo‐Wen Lin, Nien-Chi Li, Ying‐Hsuan Huang, Wen‐Chang Chang, Ben‐Kuen Chen
Abstract
The antioxidants, statins, and targeting IL-8 may provide better outcomes for treating metastatic CRC that harbors multigene mutations and anti-EGFR resistance.
Topics & Concepts
KRASCancer researchMetastasisColorectal cancerChemistryMedicineCancerBiologyInternal medicineCancer, Lipids, and MetabolismColorectal Cancer Treatments and StudiesLipid metabolism and disorders