[DDQM][HSO<sub>4</sub>]/TBHP as a Multifunctional Catalyst for the Metal Free Tandem Oxidative Synthesis of 2-Phenylquinazolin-4(3<i>H</i>)-ones
Bidyutjyoti Dutta, Nilakshi Dutta, Apurba Dutta, Montu Gogoi, Sanjay Mehra, Arvind Kumar, Kalyanjyoti Deori, Diganta Sarma
Abstract
A bifunctional ionic liquid (IL) [DDQM][HSO 4 ] has been designed and explored as a three-way catalyst for the synthesis of 2-phenylquinazolin-4(3 H )-ones from anthranilamide and benzyl alcohol in 3.5 min incorporating microwave irradiation. Photochemically the reaction proceeds for 4 h at room temperature and thermally for 8 h at 120 °C. Further IL-assisted metal, solvent, and base free in situ oxidation of benzyl alcohols to aldehydes shows its task specificity. The multifunctionality of the IL was reestablished with the synthesis of two Wnt pathway antagonists.
Topics & Concepts
CatalysisBifunctionalIonic liquidBenzyl alcoholChemistryTandemMicrowave irradiationSolventOxidative phosphorylationMetalAlcoholCombinatorial chemistryOrganic chemistryMaterials scienceComposite materialBiochemistryQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationMulticomponent Synthesis of Heterocycles