Iron-catalyzed decarboxylative radical addition to chiral azomethine imines upon visible light
Arona Fall, Mihaela Magdei, Mariia Savchuk, Sylvain Oudeyer, Hélène Beucher, Jean‐François Brière
Abstract
Herein, we disclose an eco-efficient redox-neutral iron-catalyzed decarboxylative radical addition to chiral azomethine imines upon visible light (427 nm) giving cyclic hydrazine derivatives with dr ranging from 82 : 18 to >96 : 4. This earth-abundant metal promoted sequence proceeds efficiently under ligand-free conditions based on a LMCT process and opens a route to new chiral heterocycles.
Topics & Concepts
CatalysisChemistryVisible spectrumPhotochemistryOrganic chemistryMaterials scienceOptoelectronicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques