The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity
Vivien Pósa, Bálint Hajdu, Gábor G. Tóth, Orsolya Dömötör, Christian R. Kowol, Bernhard K. Keppler, Gabriella Spengler, Béla Gyurcsik, Éva A. Enyedy
Topics & Concepts
ChemistryLipophilicityCopperChelationSemicarbazoneTopoisomeraseThio-CytotoxicityAqueous solutionCoordination complexMetalDNACombinatorial chemistryMedicinal chemistryStereochemistryInorganic chemistryIn vitroOrganic chemistryBiochemistryMetal complexes synthesis and propertiesSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity