Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma
Lele Zhou, Qun Guan, Wei Zhou, Jing‐Lan Kan, Yu‐Bin Dong
Abstract
An iminium-linked cationic covalent organic framework-based nanoagent that is synthesized under ambient conditions achieves synergistic RNA interference and metabolic therapy via effective siRNA delivery and timely lysosome escape.
Topics & Concepts
IminiumCationic polymerizationCovalent bondRNA interferenceChemistryInterference (communication)FibrosarcomaRNACombinatorial chemistryBiochemistryOrganic chemistryComputer scienceBiologyGeneGeneticsCatalysisComputer networkChannel (broadcasting)Covalent Organic Framework ApplicationsMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranostics