Camps Reaction and Related Cyclizations
Alexander S. Fisyuk, A. S. Kostyuchenko, Д. С. Гончаров
Abstract
The review presents analysis of the literature on the intramolecular cyclization of N-(2-acylaryl)amides, known as the Camps reaction, as well as close analogs of these compounds, N-(3-oxoalkenyl)- and N-(3-oxoalkyl)amides, which contain an amide and a carbonyl groups and react by the aldol–crotonic type. The potential, limitations, and regularities of these reactions leading to quinoline-2(1H)-ones, quinoline-4(1H)-ones, pyridin-2-ones, pyridin-4-ones, as well as their hydrogenated derivatives are highlighted.
Topics & Concepts
ChemistryQuinolineAldol reactionIntramolecular forceAmideMedicinal chemistryOrganic chemistryStereochemistryCatalysisChemical synthesis and alkaloidsSynthesis and Reactivity of HeterocyclesAsymmetric Synthesis and Catalysis