Is there a relationship between Helicobacter pylori vacA i1 or i2 alleles and development into peptic ulcer and gastric cancer? A meta-analysis study on an Iranian population
Masoud Keikha
Abstract
Helicobacter pylori has several virulance factor i.e. VacA, CagA, BabA, SabA, AlpA, AlpB and etc. VacA has several polymorphic region in the nucleotide sequence such as s,m,i,d and, c. It has been suggested that each variation in these polymorphic region has been influenced the toxicity of VacA toxin. We performed a comprehensive meta-analysis to determine the main role of VacAi1/i2 in development into peptic ulcer and gastric cancer in an Iranian population.
Topics & Concepts
Helicobacter pyloriCagAPeptic ulcerCancerPopulationAlleleGastroenterologyMeta-analysisToxinPepticInternal medicineMedicineBiologyMicrobiologyGeneticsGeneVirulenceEnvironmental healthHelicobacter pylori-related gastroenterology studiesVeterinary medicine and infectious diseasesGastroesophageal reflux and treatments