Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2
Yong Fu, Yan Ding, Qinghui Wang, Feng Zhu, Yulong Tan, Lu Xiao, Bo Guo, Qingfeng Zhang, Yaming Cao, Taiping Liu, Liwang Cui, Wenyue Xu
Abstract
from inducing macrophages to release MCP-1. Therefore, we highlight a previously unrecognized immune suppression strategy of malaria parasites and uncover the fundamental mechanism of sFGL2 to suppress host innate immune responses.
Topics & Concepts
Immune systemInnate immune systemBiologyImmunologyMalariaFOXP3Plasmodium falciparumSpleenMonocyteComplement system in diseasesMalaria Research and ControlMosquito-borne diseases and control