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The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Salomé Adam, Silvia Emma Rossi, Nathalie Moatti, Mara De Marco Zompit, Yibo Xue, Timothy F. Ng, Alejandro Álvarez-Quilón, Jessica Desjardins, Vivek Bhaskaran, Giovanni Martino, Dheva Setiaputra, Sylvie M. Noordermeer, Toshiro K. Ohsumi, Nicole Hustedt, Rachel K. Szilard, Natasha Chaudhary, Meagan Munro, Artur Veloso, Henrique Melo, Shou Yun Yin, Robert Papp, Jordan T.F. Young, Michael Zinda, Manuel Stucki, Daniel Durocher

2021Nature Cancer120 citationsDOI

Topics & Concepts

GeneticsBiologyChromosomeCancer researchComputational biologyGeneDNA Repair MechanismsPARP inhibition in cancer therapyBRCA gene mutations in cancer
The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer | Litcius