Azole-Pyrimidine Hybrid Anticancer Agents: A Review of Molecular Structure,Structure Activity Relationship, and Molecular Docking
Cosmas Chinweike Eze, Mercy A. Ezeokonkwo, David Izuchukwu Ugwu, Uchenna Florence Eze, Ebuka Leonard Onyeyilim, Izuchi Solomon Attah, Ifeoma Vivian Okonkwo
Abstract
Cancer has emerged as one of the leading causes of death globally, partly due to the steady rise in anticancer drug resistance. Pyrimidine and pyrimidine-fused heterocycles are some of the privileged scaffolds in medicine, as they possess diverse biological properties. Pyrimidines containing azole nucleus possess inestimable anticancer potency and can potentially regulate cellular pathways for selective anticancer activity. The present review outlines the molecular structure of pyrimidine-fused azoles with significant anticancer activity. The structure activity relationship and molecular docking studies have also been discussed. The current review is the first complete compilation of significant literature on the proposed topic from 2016 to 2020. The information contained in this review offers a useful insight to chemists in the design of new and potent anticancer azole-pyrimidine analogues.