EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
Marco Trizzino, Avery Zucco, Sandra Deliard, Fang Wang, Elisa Barbieri, Filippo Veglia, Dmitry I. Gabrilovich, Alessandro Gardini
Abstract
However, differentiating macrophages present a very different EGR1 binding pattern. We identify novel binding sites of EGR1 at a large set of inflammatory enhancers, even in the absence of its binding motif. We show that EGR1 repressive activity results in suppression of inflammatory genes and is mediated by the NuRD corepressor complex.
Topics & Concepts
EGR1EnhancerPsychological repressionTranscription factorEpigeneticsCell biologyTranscription (linguistics)InflammationMacrophageBiologyCancer researchChemistryImmunologyGene expressionGeneticsGeneIn vitroPhilosophyLinguisticsEpigenetics and DNA MethylationImmune cells in cancerCancer-related gene regulation