Suppression of malignant melanoma by knocking down growth differentiation factor-15 via inhibiting PTEN/PI3K/AKT signaling pathway
Jun Zhou, Caifeng Chen
Abstract
GDF15 regulated the cell proliferation, apoptosis, migration, invasion, and EMT process of M14 and M21 cell lines through targeting PTEN/PI3K/AKT signaling pathway. This research provides a novel prevention and treatment strategy for melanoma.
Topics & Concepts
PTENPI3K/AKT/mTOR pathwayProtein kinase BCancer researchSignal transductionCell growthChemistryApoptosisCell biologyBiologyBiochemistryGDF15 and Related BiomarkersCircular RNAs in diseasesMicroRNA in disease regulation