Trends in the activity of mold-active azole agents against <i>Aspergillus fumigatus</i> clinical isolates with and without <i>cyp51</i> alterations from Europe and North America (2017–2021)
Michael A. Pfaller, Cecília G Carvalhaes, Paul R. Rhomberg, L. M. Desphande, Mariana Castanheira
Abstract
A few microbiology laboratories perform antifungal susceptibility testing locally for systemically active antifungal agents. The identification of emerging azole-resistant Aspergillus fumigatus is worrisome. As such, there is a critical role for antifungal surveillance in tracking emerging resistance among both common and uncommon opportunistic fungi. Differences in the regional prevalence and antifungal resistance of these fungi render local epidemiological knowledge essential for the care of patients with a suspected invasive fungal infection.
Topics & Concepts
AzoleAspergillus fumigatusPosaconazoleVoriconazoleMicrobiologyAspergillusAspergillosisBiologyAntifungalImmunologyAntifungal resistance and susceptibilityFungal Infections and StudiesPeptidase Inhibition and Analysis