CRISPR/Cas9 genome-edited universal CAR T cells in patients with relapsed/refractory lymphoma
Yelei Guo, Chuan Tong, Liping Su, Wenying Zhang, Hejin Jia, Yang Liu, Qingming Yang, Zhiqiang Wu, Yao Wang, Weidong Han
Abstract
Chimeric antigen receptor (CAR)-modified T cells have been reported to successfully treat patients with hematological malignancies. 4]
Topics & Concepts
CRISPRGenome editingLymphomaGenomeRefractory (planetary science)MedicineVirologyBiologyCancer researchGeneticsGeneInternal medicineAstrobiologyCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsVirus-based gene therapy research