Design, synthesis, anti-tumor activity and mechanism of novel PROTACs as degraders of PD-L1 and inhibitors of PD-1/PD-L1 interaction
Feng Zhang, Qimeng Yu, Caiyun Wu, Shishi Sun, Yu Wang, Rui Wang, Zejie Chen, Hua Zhang, Xuqiong Xiong, Annoor Awadasseid, Guo‐Wu Rao, Xiaoyin Zhao, Wen Zhang, Xiaoyin Zhao, Wen Zhang
Topics & Concepts
ChemistryPD-L1Ligand (biochemistry)Structure–activity relationshipCombinatorial chemistrySmall moleculeMechanism (biology)Computational biologyCancerStereochemistryPharmacologyBiochemistryIn vitroReceptorImmunotherapyBiologyGeneticsPhilosophyEpistemologyProtein Degradation and InhibitorsCAR-T cell therapy researchPeptidase Inhibition and Analysis