Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2<i>H</i>‐Chromenes
Qingjing Yang, Sifeng Li, Jun Wang
Abstract
Abstract A copper/( R )‐DTBM‐SEGPHOS‐catalyzed enantioselective hydroamination of 2 H ‐chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4‐aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions.
Topics & Concepts
HydroaminationEnantioselective synthesisHydroxylamineChemistryCopperCatalysisCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesAxial and Atropisomeric Chirality Synthesis