Regioselective C-3-alkylation of quinoxalin-2(1<i>H</i>)-ones <i>via</i> C–N bond cleavage of amine derived Katritzky salts enabled by continuous-flow photoredox catalysis
Gandhari Kishor, V. Ramesh, Vadithya Ranga Rao, Srihari Pabbaraja, Praveen Reddy Adiyala
Abstract
)-ones were synthesized in moderate to high yields. Further this environmentally benign protocol is carried out in a PFA (Perfluoroalkoxy alkane) capillary based micro reactor under blue LED irradiation, enabling excellent yields (72% to 91%) and shorter reaction times (0.81 min) as compared to a batch system (16 h).
Topics & Concepts
RegioselectivityAlkylationChemistryPhotoredox catalysisBond cleavageAmine gas treatingCleavage (geology)CatalysisContinuous flowMedicinal chemistryTransition metalCombinatorial chemistryPhotochemistryOrganic chemistryPhotocatalysisMaterials scienceMechanicsComposite materialPhysicsFracture (geology)Radical Photochemical ReactionsSynthesis and Biological EvaluationCatalytic C–H Functionalization Methods