Genomic Analysis Revealed the International and Domestic Transmission of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in Chinese Pediatric Patients
Muxiu Jiang, Heng Li, Xiao Liu, Nan Shen, Yuanjie Zhou, Wenting Song, Xing Wang, Qing Cao, Zhemin Zhou
Abstract
(CRKP) infection in pediatric patients differs from that in adults patients in terms of both genetic and phenotypic features, which remain to be elucidated. We present a summary of prevalent CRKP isolates from Chinese pediatric patients over 8 years, demonstrating the prevalence and clinical importance of New Delhi metallo-β-lactamase genes in pediatric patients, mainly describing the genomic features of two predominant CRKP clones (ST11 and ST14) in Chinese children, and identifying four carbapenemase-encoding plasmids that contribute to the transmission of most carbapenemase genes in hospitals. Overall, our research provides valuable information about the international and domestic transmission of CRKP isolates that are prevalent in Chinese children and shows the urgent need for genome sequencing-based surveillance systems for monitoring the transmission of CRKP.