Effectiveness of 2-Dose Vaccination with mRNA COVID-19 Vaccines Against COVID-19–Associated Hospitalizations Among Immunocompromised Adults — Nine States, January–September 2021
Peter J. Embí, Matthew E. Levy, Allison L. Naleway, Palak Patel, Manjusha Gaglani, Karthik Natarajan, Kristin Dascomb, Toan C. Ong, Nicola P. Klein, I‐Chia Liao, Shaun J. Grannis, Jungmi Han, Edward Stenehjem, Margaret M. Dunne, Ned Lewis, Stephanie A. Irving, Suchitra Rao, Charlene McEvoy, Catherine H. Bozio, Kempapura Murthy, Brian E. Dixon, Nancy Grisel, Duck‐Hye Yang, Kristin Goddard, Anupam B. Kharbanda, Sue Reynolds, Chandni Raiyani, William F. Fadel, Julie Arndorfer, Elizabeth Rowley, Bruce Fireman, Jill M. Ferdinands, Nimish R. Valvi, Sarah W. Ball, Ousseny Zerbo, Eric P. Griggs, Patrick K. Mitchell, Rachael M. Porter, Salome A. Kiduko, Lenee Blanton, Yan Zhuang, Andrea Steffens, Sarah E. Reese, Natalie Olson, Jeremiah Williams, Monica Dickerson, Meredith McMorrow, Stephanie J. Schrag, Jennifer R. Verani, Alicia M. Fry, Eduardo Azziz‐Baumgartner, Michelle A. Barron, Mark G. Thompson, Malini B. DeSilva
Abstract
], N04, and R18), or organ or stem cell transplant (ICD-10 codes: T86 [except T86.82-T86.84, T86.89, and T86.9], D47.Z1, Z48.2, Z94, and Z98.85). Index date was defined as the date of respiratory specimen collection associated with the most recent positive or negative SARS-CoV-2 test result before hospitalization or the hospitalization date if testing only occurred after admission. Kaiser Permanente Northwest 3,531 (5) 1,716 (49) 347 (10) 1,117 (6) 614 (55) 47 (4) Regenstrief Institute 19,099 (28) 6,188 (32) 3,562 (19) 3,000 (15) 1,121 (37) 320 (11) University of Colorado 11,302 (16) 2,469 (22) 1,101 (10) 4,651 (23) 1,351 (29) 244 (5) Age group, yrs 18-49 15,891 (23) 3,469 (22) 0.62 3,542 (22) 0.43 2,291 (11) 709 (31) 0.47 241 (11) 0.21 50-64 13,669 (20) 4,597 (34) 2,989 (22) 4,524 (23) 1,874 (41) 411 (9) 65-74 15,715 (23) 7,477 (48) 2,101 (13) 6,149 (31) 3,429 (56) 431 (7) 75-84 14,421 (21) 8,270 (57) 1,491 (10) 5,064 (25) 3,201 (63) 341 (7) 85 9,420 (14) 5,643 (60) 838 (9) 2,073 (10) 1,351 (65) 113 (5) Sex Men 30,625 (44) 13,106 (43) -0.01 5,406 (18) -0.12 9,552 (48) 5,082 (53) -0.02 762 (8) -0.04 Women 38,491 (56) 16,350 (42) 5,555 (14) 10,549 (52) 5,482 (52) 775 (7) Race, (regardless of ethnicity) White 45,206 (65) 20,094 (44) 0.28 6,512 (14) 0.20 13,834 (69) 7,344 (53) 0.23 985 (7) 0.16 Black 7,204 (10) 2,107 (29) 1,274 (18) 1,821 (9) 819 (45) 182 (10) Other 5,382 (8) 3,126 (58) 722 (13) 1,725 (9) 1,164 (67) 110 (6) Unknown 11,324 (16) 4,129 (36) 2,453 (22) 2,721 (14) 1,237 (45) 260 (10) Ethnicity Hispanic 9,415 (14) 3,464 (37) 0.10 2,069 (22) 0.26 2,786 (14) 1,366 (49) 0.09 271 (10) 0.14 Non-Hispanic 48,146 (70) 20,753 (43) 6,498 (13) 14,448 (72) 7,544 (52) 1,020 (7) Unknown 11,555 (17) 5,239 (45) 2,394 (21) 2,867 (14) 1,654 (58) 246 (9) Chronic respiratory condition Has chronic respiratory condition 44,264 (64) 19,788 (45) 0.11 6,891 (16) -0.03 13,652 (68) 7,331 (54) 0.07 1,084 (8) 0.06 No chronic respiratory condition 24,852 (36) 9,668 (39) 4,070 (16) 6,449 (32) 3,233 (50) 453 (7) ICU admission Admitted to ICU 10,939 (16) 4,278 (39) -0.06 1,700 (16) -0.01 4,285 (21) 1,977 (46) -0.13 361 (8) 0.06 Not admitted to ICU 58,177 (84) 25,178 (43) 9,261 (16) 15,816 (79) 8,587 (54) 1,176 (7) COVID-19 vaccination status Unvaccinated 39,660 (57) 0 (-) -9,853 (25) 0.94 9,537 (47) 0 (-) -1,127 (12) 0.60 Moderna (mRNA-1273) 12,341 (18) 12,341 (100) 357 (3) 4,337 (22) 4,337 (100) 138 (3) Pfizer-BioNTech (BNT162b2) 17,115 (25) 17,115 (100) 751 (4) 6,227 (31) 6,227 (100) 272 (4)