Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues
Francesca Sanguedolce, Beppe Calò, Marco Chirico, Simona Tortorella, Giuseppe Carrieri, Luigi Cormio
Abstract
Large cell neuroendocrine carcinoma (LCNEC) of the urinary tract is a high-grade neuroendocrine tumor with distinct pathological features, usually portending an aggressive clinical behavior in comparison to conventional urothelial carcinoma. Due to its low prevalence, little is known about its clinical management and there is no current standard of care. The aim of this review was to summarize the current knowledge about LCNEC of the bladder, ureter and kidney, with relevance to diagnostic, prognostic and therapeutic issues, through a systematic analysis of clinical, pathological and outcome data retrieved from the literature.
Topics & Concepts
PathologicalMedicineUrinary systemClinical significanceCarcinomaOncologyNeuroendocrine carcinomaPathologyUreterUrinary bladderGastrointestinal tractNeuroendocrine tumorsInternal medicineUrologyNeuroendocrine Tumor Research AdvancesLung Cancer Research StudiesUrinary and Genital Oncology Studies