A Novel Deletion Mutation in <i>pmrB</i> Contributes to Concurrent Colistin Resistance in Carbapenem-Resistant Escherichia coli Sequence Type 405 of Clinical Origin
Ching-Hsun Wang, L. Kristopher Siu, Feng‐Yee Chang, Yu-Kuo Tsai, Yi-Tsung Lin, Sheng-Kang Chiu, Li-Yueh Huang, Jung-Chung Lin
Abstract
We report the first clinical Escherichia coli strain EC3000 with concomitant chromosomal colistin and carbapenem resistance. A novel in-frame deletion, Δ6-11 (RPISLR), in pmrB that contributes to colistin resistance was verified using recombinant DNA techniques. Although being less fit than the wild-type (WT) strain or EC3000 revertant (chromosomal replacement of WT pmrB in EC3000), a portion of serially passaged EC3000 strains preserving colistin resistance without selective pressure raises the concern for further spread.
Topics & Concepts
ColistinEscherichia coliBiologyPlasmidCarbapenemMicrobiologyDrug resistanceStrain (injury)MutationRecombinant DNAEnterobacteriaceaeGeneticsDNAGeneAntibioticsAnatomyAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyBacterial Genetics and Biotechnology