Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer
Jianbo Pan, Lili Yu, Qingwei Wu, Xiaoqing Lin, Shuang Liu, Shaohui Hu, Christian Rosa, Daniel Eichinger, Ignacio Pino, Heng Zhu, Jiang Qian, Yi Huang
Abstract
CTAG1A, DDX4 and MAGEC2) for diagnosis of early stage LC with 73.5% sensitivity at >85% specificity. In Phase III, the performance of this biomarker panel was confirmed with an independent cohort, comprised of 88 early stage LC patients, 18 LBL patients, and 36 healthy subjects. Finally, a blind test on 178 serum samples was conducted to confirm the performance of the biomarker panel. In summary, this study demonstrates for the first time that an integrated panel of IgA/IgG autoantigens can serve as valuable biomarkers to further improve the performance of early diagnosis of LC.
Topics & Concepts
BiomarkerSerologyIsotypeLung cancerImmunologyAntibodyMedicineAutoantibodyImmunoglobulin GCohortStage (stratigraphy)Biomarker discoveryImmunoglobulin MInternal medicineBiologyProteomicsMonoclonal antibodyGeneBiochemistryPaleontologyMonoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune ResponsesGlycosylation and Glycoproteins Research