Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension
Nicolas Philip, Xin Yun, Hongyang Pi, Samuel S. Murray, Zack Hill, Jay-Miguel Fonticella, Preston Perez, Cissy Zhang, Wimal Pathmasiri, Susan Sumner, Laura Servinsky, Haiyang Jiang, John Huetsch, William M. Oldham, Scott Visovatti, Peter J. Leary, Sina A. Gharib, Evan L. Brittain, Catherine E. Simpson, Anne Le, Larissa A. Shimoda, Karthik Suresh
2024American Journal of Physiology-Lung Cellular and Molecular Physiology15 citationsDOIOpen Access PDF
Abstract
In this paper, we explore the link between metabolism and intracellular calcium levels in microvascular endothelial cells (MVECs) in pulmonary arterial hypertension (PAH). We show that fatty acid oxidation promotes sensitivity of the transient receptor potential vanilloid-4 (TRPV4) calcium channel in MVECs isolated from a rodent model of PAH.
Topics & Concepts
ChemistryMetabolismFatty acidIntracellularFatty acid metabolismCalcium in biologyCalciumBiochemistryEndocrinologyInternal medicinePharmacologyBiologyMedicineOrganic chemistryPulmonary Hypertension Research and TreatmentsCardiovascular, Neuropeptides, and Oxidative Stress ResearchIon Channels and Receptors