Antimicrobial susceptibility Patterns of Bacteria that Commonly Cause Bacteremia at a Tertiary Hospital in Zambia
Maisa Kasanga, Steward Mudenda, Makomani Siyanga, Misheck Chileshe, Mark J Mwiikisa, Maika Kasanga, Benjamin Bisesa Solochi, Theodore Gondwe, Timothy Kantenga, Aaron Shibemba, Mwansa Chitalu, Ruth Nakazwe, Jian Wu
Abstract
Background: Bloodstream infections and antimicrobial resistance cause global increases in morbidity and mortality. Aim: We evaluated the antimicrobial susceptibility patterns of bacteria that commonly cause bacteremia in humans. Materials & methods: We conducted a retrospective cross-sectional study at the University Teaching Hospitals in Lusaka, Zambia, using Laboratory Information Systems. Results: The commonest isolated bacteria associated with sepsis were Klebsiella pneumoniae. The distribution of bacteria associated with bacteremia in different wards and departments at University Teaching Hospitals was statistically significant (χ2 = 1211.518; p < 0.001). Conclusion: K. pneumoniae, Escherichia coli, Pantoea agglomerans and Enterococcus species have developed high resistance levels against ampicillin, cefotaxime, ciprofloxacin, gentamicin and trimethoprim/sulfamethoxazole and a very low resistance levels against imipenem and Amikacin.