Synthesis, antioxidant activity, and α‐glucosidase enzyme inhibition of α‐aminophosphonate derivatives bearing piperazine‐1,2,3‐triazole moiety
Madhu Kumar Reddy Kandula, Mohan Gundluru, N. Bakthavatchala Reddy, G. Sravya, Peddanna Kotha, Grigory V. Zyryanov, C. Sridevi, C. Suresh Reddy
Abstract
Abstract A novel series of piperazine‐1,2,3‐triazole bearing dimethyl(((2‐(4‐((1H‐1,2,3‐triazole‐4‐yl)methyl)piperazin‐1‐yl)ethylamino)(2‐hydroxyaryl)methyl)phosphonate derivatives have been prepared via copper‐catalyzed azide‐alkyne 1,3‐dipolar cycloaddition (CuAAC) (Click Reaction) and Schiff base reactions. The synthesized compounds were confirmed by spectral characterization ( 1 H, 13 C and 31 P NMR, and mass). The title compounds were evaluated for in vitro alpha glucosidase enzyme inhibition and in vitro antioxidant activity using DPPH and H 2 O 2 methods.
Topics & Concepts
ChemistryPiperazineClick chemistryMoiety1,2,3-TriazoleTriazoleAzideCycloadditionStereochemistryDPPHProton NMRAntioxidantOrganic chemistryCombinatorial chemistryCatalysisClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity