Early-life exercise extends healthspan but not lifespan in mice
Mengya Feng, Min Li, Jing Lou, Guiling Wu, Tianpeng Gao, Fangqin Wu, Yanzhen Tan, Nini Zhang, Yong Zhao, Zhao Lin, Jia Li, Changhong Shi, Xing Zhang, Jiankang Liu, Feng Gao
Abstract
It is well-known that physical activity exerts health benefits, yet the potential impacts of early-life regular exercise on later-life health and lifespan remains poorly understood. Here, we demonstrate that 3 months of early-life exercise in mice results in lasting health benefits, extending healthspan, but not lifespan. C57BL/6J mice underwent swimming exercise from 1 to 4 months of age, followed by detraining for the remainder of their lives. While early-life exercise did not extend the overall lifespan, it significantly improved healthspan in both male and female mice, as evidenced by enhanced systemic metabolism, cardiovascular function, and muscle strength, as well as reduced systemic inflammation and frailty in aged mice. Multiple-organ transcriptome analyses identified enhanced fatty acid metabolism in skeletal muscles as a major feature in aged mice that underwent early-life exercise. These findings reveal the enduring long-term health benefits of early-life exercise, highlighting its pivotal role in improving healthspan. Exercise exerts health benefits, yet the long-term effects of early-life regular exercise on later-life health and lifespan remain poorly understood. Here, the authors show early-life exercise in mice extends healthspan, though it does not affect lifespan.