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Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

Fansen Meng, Zhengyang Yu, Dan Zhang, Shasha Chen, Hongxin Guan, Ruyuan Zhou, Qirou Wu, Qian Zhang, Shengduo Liu, Mukesh Kumar Venkat Ramani, Bing Yang, Xiaoqun Ba, Jing Zhang, Jun Huang, Xueli Bai, Jun Qin, Xin‐Hua Feng, Songying Ouyang, Yan Zhang, Tingbo Liang, Pinglong Xu

2021Molecular Cell128 citationsDOI

Topics & Concepts

BiologyInnate immune systemStingIRF3Cell biologySuppressorCarcinogenesisCancer researchTANK-binding kinase 1MutantSignal transductionGeneticsCancerGeneImmune systemProtein kinase BEngineeringAerospace engineeringMAP kinase kinase kinaseinterferon and immune responsesHippo pathway signaling and YAP/TAZViral Infections and Vectors
Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity | Litcius