Human Papillomavirus 16 L2 Recruits both Retromer and Retriever Complexes during Retrograde Trafficking of the Viral Genome to the Cell Nucleus
David Pim, Justyna Broniarczyk, Abida Siddiqa, Paola Massimi, Lawrence Banks
Abstract
Previous studies identified sorting nexins 17 and 27, as well as the retromer complex, as playing a role in HPV infection. This study shows that the newly identified retriever complex also plays an important role and begins to shed light on how both sorting nexins contribute to retromer and retriever recruitment during the infection process.
Topics & Concepts
RetromerBiologyVirologyNucleusCell biologyEndosomeHuman papillomavirusGenomeGeneticsCellGeneInternal medicineMedicineVirus-based gene therapy researchParvovirus B19 Infection StudiesCancer-related Molecular Pathways