Methylation-mediated LINC00261 suppresses pancreatic cancer progression by epigenetically inhibiting c-Myc transcription
Songsong Liu, Yao Zheng, Yujun Zhang, Junfeng Zhang, Fuming Xie, Shixiang Guo, Jianyou Gu, Jiali Yang, Ping Zheng, Jiejuan Lai, Liangyu Yin, Huaizhi Wang
Abstract
Our findings indicate that methylation-mediated LINC00261 suppresses PC progression by epigenetically repressing c-Myc expression. These findings expand the therapeutic potential of LINC00261, possibly providing evidence to support the development of epigenetic drugs or therapeutic strategies. This research adds further insights into the etiology of PC and indicates that LINC00261 may be a prognostic and therapeutic target in PC.
Topics & Concepts
Chromatin immunoprecipitationBiologyDNA methylationMethylationCancer researchEpigeneticsIn vivoPancreatic cancerTranscription factorDemethylationCarcinogenesisTranscription (linguistics)ChromatinCell biologyMolecular biologyPromoterGene expressionCancerDNAGeneGeneticsPhilosophyLinguisticsCancer-related molecular mechanisms researchRNA modifications and cancerEpigenetics and DNA Methylation