From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement
Loïs Coënon, Martín Villalba
Abstract
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and increasing its efficacy would improve cancer immunotherapy. CD16a is a receptor for the Fc portion of IgGs and is responsible to trigger NK cell-mediated ADCC. The knowledge of the mechanism of action of CD16a gave rise to several strategies to improve ADCC, by working on either the mAbs or the NK cell. In this review, we give an overview of CD16a biology and describe the latest strategies employed to improve antibody-dependent NK cell cytotoxicity.
Topics & Concepts
Antibody-dependent cell-mediated cytotoxicityCytotoxicityCytotoxic T cellMonoclonal antibodyImmunotherapyCytolysisCancer immunotherapyAntibodyNatural killer cellImmunologyChemistryCancer researchImmune systemBiologyIn vitroBiochemistryCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies ResearchImmune Cell Function and Interaction