Emergent synthetic methods for the modular advancement of sp<sup>3</sup>-rich fragments
Max J. Caplin, Daniel J. Foley
Abstract
This Perspective reviews recently developed methods that are likely to be of value to the elaboration of sp<sup>3</sup>-rich fragments from carbon-centred vectors, whilst maintaining key fragment-to-target binding interactions.
Topics & Concepts
Modular designFragment (logic)Perspective (graphical)ElaborationKey (lock)Value (mathematics)Computational biologyComputer scienceCombinatorial chemistryStereochemistryChemistryBiologyArtificial intelligenceProgramming languageHumanitiesPhilosophyMachine learningOperating systemClick Chemistry and ApplicationsChemical Synthesis and AnalysisSynthesis and Catalytic Reactions