Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents
Thomas Radtke, Agnė Ulytė, Milo A. Puhan, Susi Kriemler
Abstract
Discussion | In this study, initial vaccine-elicited neutralizing antibody titers were negatively associated with age, resulting in a diminished ability to neutralize SARS-CoV-2 in vitro. Neutralizing titers against P.1 were reduced across all ages, although the magnitude of the age-dependent difference was smaller. Interim clinical trial data did not identify age as a contributing factor to overall vaccine efficacy. 1 However, recent studies in vaccinated populations have found a measurable increase in COVID-19 cases among vaccinated older adults. 3,4 The data from the current study are consistent with neutralizing antibody levels playing an important role in this observation.
Topics & Concepts
MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CohortCoronavirus disease 2019 (COVID-19)Pediatrics2019-20 coronavirus outbreakCohort studyTerm (time)Internal medicineVirologyDiseaseOutbreakInfectious disease (medical specialty)Quantum mechanicsPhysicsLong-Term Effects of COVID-19Psychosomatic Disorders and Their TreatmentsCOVID-19 and Mental Health