SLAM medical imaging enabled by a pre-chirp and gain jointly managed Yb-fiber laser
Yuting Xing, Runzhi Chen, Lihao Zhang, Yaobing Chen, Shuang‐Nan Zhang, Xincai Diao, Yang Liu, Yishi Shi, Zhiyi Wei, Guoqing Chang
Abstract
We demonstrate a pre-chirp and gain jointly managed Yb-fiber laser that drives simultaneous label-free autofluorescence-multiharmonic (SLAM) medical imaging. We show that a gain managed Yb-fiber amplifier produces high-quality compressed pulses when the seeding pulses exhibit proper negative pre-chirp. The resulting laser source can generate 43-MHz, 34-fs pulses centered at 1110 nm with more than 90-nJ energy. We apply this ultrafast source to SLAM imaging of cellular and extracellular components in various human tissues of intestinal adenocarcinoma, lung adenocarcinoma, and liver.
Topics & Concepts
ChirpLaserFiber laserOpticsMaterials scienceUltrashort pulseOptical fiberAutofluorescenceFiberAmplifierOptoelectronicsFluorescencePhysicsCMOSComposite materialAdvanced Fluorescence Microscopy TechniquesOptical Coherence Tomography ApplicationsAdvanced Fiber Laser Technologies