Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation
Shihab Uddin, Md. Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto
Abstract
We report a new series of lipid-based biocompatible ionic liquids (LBILs) consisting of the long-chain phosphonium compound 1,2-dimyristoyl-sn-glycero-3-ethyl-phosphatidylcholine as the cation and the long-chain fatty acids stearic acid, oleic acid, or linoleic acid as anions. These materials were found to be completely miscible with many polar and nonpolar organic solvents as well as dispersible in water. These LBILs also exhibited excellent biocompatibility with an artificial three-dimensional human epidermis model.
Topics & Concepts
Biocompatible materialIonic liquidPhosphoniumBiocompatibilityChemistryPhosphatidylcholineIonic bondingChemical engineeringOrganic chemistryPhospholipidCombinatorial chemistryIonMembraneBiochemistryCatalysisBiomedical engineeringEngineeringMedicineIonic liquids properties and applicationsElectrochemical sensors and biosensorsLipid Membrane Structure and Behavior