The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain
Philip Hampel, Kerstin Römermann, Martina Gramer, Wolfgang Löscher
Topics & Concepts
BumetanidePharmacologyEpilepsyPharmacodynamicsNeurosciencePharmacokineticsChemistryMedicinePsychologyBiochemistryIon transporterMembraneNeuroscience and Neuropharmacology ResearchEpilepsy research and treatmentPharmacological Effects and Toxicity Studies