Non-canonical roles of NAMPT and PARP in inflammation
Francisco J. Martínez-Morcillo, Joaquín Cantón-Sandoval, Teresa Martínez‐Menchón, R. Corbalán-Vélez, Pablo Mesa-del-Castillo, Ana B. Pérez‐Oliva, Diana García‐Moreno, Víctoriano Mulero
Abstract
-consuming enzyme, poly(ADP-ribose) polymerase (PARP). The extracurricular roles of these enzymes, i.e. the proinflammatory role of NAMPT after its release, and the ability of PARP to promote a novel form of cell death, known as parthanatos, upon hyperactivation are revised and discussed in the context of several chronic inflammatory diseases.
Topics & Concepts
NAD+ kinaseNicotinamide adenine dinucleotidePoly ADP ribose polymeraseInflammationContext (archaeology)DNA repairNicotinamide mononucleotideBiologyProinflammatory cytokineCell biologyChromatin remodelingEpigeneticsChromatinEnzymeBiochemistryImmunologyDNAPolymerasePaleontologyGenePARP inhibition in cancer therapySirtuins and Resveratrol in MedicineCalcium signaling and nucleotide metabolism