Antimicrobial activity and molecular docking screening of bioactive components of Antirrhinum majus (snapdragon) aerial parts
Fadi G. Saqallah, Wafaa M A Al Shaikh Hamed, Wamidh H. Talib, Roza Dianita, Habibah A. Wahab
Abstract
Background: 's sample preparation and extraction methods on the plant-aerial parts' phytochemical contents and antimicrobial activity. Furthermore, the microbial targets of the extracts' secondary metabolites are inspected using molecular docking simulations. Methods: . Besides, molecular docking of 66 reported isolated compounds was conducted against various microbial targets. Results: 's compounds could neither inhibit the 30S ribosomal subunit nor muramyl ligase E. Conclusion: fresh aerial parts gave higher flavonoid and phenolic content contributing to its antimicrobial properties. These flavonoids and phenolic compounds are predicted to have a crucial role in inhibiting fungal sterol 14-demethylase, and bacterial dihydropteroate synthase and gyrase B subunit proteins.