Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer
Kerstin Rhiem, Bernd Auber, Susanne Briest, Nicola Dikow, Nina Ditsch, Neda Dragicevic, Sabine Grill, Eric Hahnen, Judit Horváth, Bernadette Jaeger, Karin Kast, Marion Kiechle, Elena Leinert, Susanne Morlot, Michael Püsken, Dieter Schäfer, Sarah Schott, Christopher Schroeder, Ulrike Siebers‐Renelt, Christine Solbach, Nana Weber‐Lassalle, Isabell Witzel, C Zeder-Göß, Rita K. Schmutzler
Abstract
Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.